Social Anxiety Disorder Resources and Guide
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B-vitamins play a vital role in chemical processes throughout the brain and body. Research shows that unhealthy levels of essential B-vitamins like B6, B9 and B12 may contribute to poor mood and feelings related to anxiety and depression. Supplementing your diet with essential B-vitamins can have a direct effect on important neurotransmitters in the brain, such as serotonin, norepinephrine and dopamine. As well, evidence suggests that B-vitamins are important cofactors that help balance and metabolize neuro-toxic chemicals that have been linked to anxiety and depression related conditions.

In combination with natural constituents like 5-HTP, SAM-e, Hyperforin, Kava Kava, and Valerian, B-vitamins work together to help you feel better.

Vitamin B1 (Thiamine)

Thiamine is a water soluble vitamin needed in relatively small quantities, and is normally found in everyday foods like fortified breads, cereals, pasta, whole grains, lean meats, fish, peas, soybeans, and dried beans.

In a recent clinical study of vitamin B1, young women were given either a placebo or 50 mg Thiamine, every day for 2 months. Before and after taking the tablets, mood, memory, and reaction times were observed. An improvement in Thiamine status was associated with reports of being more clearheaded, composed, and having more energy. more...

Vitamin B3 (Niacin)

Niacin is a water soluble vitamin found in dairy products, lean meats, fish, poultry, nuts, and eggs. Clinical research has shown that B3 supplementation may help reduce peripheral breakdown of L-Tryptophan. Thus, L-Tryptophan will not be depleted for Niacin production in the brain, allowing it to be transported into the central nervous system. It is subsequently metabolized into 5-HTP which leads directly to Serotonin production. more...

Vitamin B5 (Pantothenic Acid)

B5 is a water soluble vitamin which can be found in milk products, eggs, and fish. Vitamin B5 has been linked to the synthesis of the neurotransmitter Acetylcholine, which performs a wide variety of functions in the central nervous system and is believed to play an important roll in memory, attention and cognitive functions in the brain. Pantothenic acid is responsible for helping to synthesize a neuro-chemical called Co-enzyme A (CoA), which is often then combined with choline to produce the neurotransmitter Acetylcholine. more...

Vitamin B6 (Pyridoxine HCL)

Pyridoxine, or B6, is a water soluble vitamin in beans, legumes, meats, nuts, eggs, fish, cereals, whole grains, and fortified breads. Recently, clinical studies have shown that B6, combined with other B-complex vitamins as well as magnesium supplementation, helps reduce levels of toxic amino acid called homocysteine. In both studies, similar therapy combinations lowered homocysteine by nearly 30%. The lowering of homocysteine may be partially responsible for reducing anxious feelings and depression based on studies involving SAM-e and methylation processes. more...

Another study confirms Pyridoxine’s direct effect on GABA and serotonin neurotransmitters. In addition, the study suggests higher doses of B6 may be a positive influence on certain types of dysphoric mental states including rage, anxiety, despair, and depression.

Vitamin B9 (Folic Acid, Folate)

B9 is closely related to biochemical processes involving S-adenosylmethionine (SAM-e) as well as homocysteine. Homocysteine is considered a dangerous and toxic byproduct of naturally occurring SAM-e in the body, an oversupply of which has been linked directly to instances of heart disease and depression related symptoms. The neurotoxic effects of homcysteine may play a role in the neurological and psychiatric disturbances associated with folate and vitamin B12 deficiency.

Folate’s mechanism of action has been implicated in biochemical processes in the brain involving neurotransmitters such as Serotonin. more...

Vitamin B12 (Cyanocobalamin)

Vitamin B12 is a water soluble vitamin naturally occurring in animal products like eggs, fish, dairy foods, and meats. Fortified breads and cereals are also a good source of B12 for vegetarians. The body is unable to produce Cyanocobalamin on its own. Therefore, it must be replenished every day through the diet. The National Institute of Health suggests vitamin B12 deficiency can contribute to feelings of anxiety and stress, as well as fatigue and weakness, tiredness, loss of appetite, weight loss, irritability, and mental confusion. more...

Vitamin H (Biotin)

Biotin is essential to the activity of many enzyme systems and for proper nervous system function. As a cofactor to numerous biological processes, Biotin works with other B-complex vitamins like B9, B12, B5 and Choline to facilitate the production of key neurotransmitters that have been linked to cognitive function, memory, and emotional well being. more...


*This information has been adapted from the Clinical Study Center ( with permission from The Medicor Labs Corporation.


National Center for Health and Wellness